Research:
Non Thermal MW Affects Gene Expression (French)

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Posted:
27 April 2000

---------- Forwarded message ----------
Date: Wed, 26 Apr 2000 05:48:03 -0500 (CDT)
From: "Roy L. Beavers" <rbeavers@llion.org>
To: emfguru <rbeavers@llion.org>
Subject: Low power (non thermal) microwave exposure produces affects in gene expression and protein kinase C in HMC-1 human mast cell line (French)..

.......This could be of some importance -- if properly followed up....!!!

Thank you Dr. French....  (A former member of this list.)

Roy Beavers (EMFguru)
roy@emfguru.com

It is better to light a single candle than to curse the darkness

People are more important than profits!!


---------- Forwarded message ----------
Date: Wed, 26 Apr 2000 16:36:00 +1000
From: "EMRAA (EMR Alliance Australia)" <emraa@ssec.org.au>
To: rbeavers@llion.org
 

Dear Roy

Dr Peter French has just forwarded me details about a study just published which may be of interest to your readers.

Best wishes
Lyn McLean


Return-Path: peterf@arnie.cfi.unsw.edu.au
Date: Wed, 26 Apr 2000 10:09:07 +0800
To: "EMRAA (EMR Alliance Australia)" <emraa@ssec.org.au>
From: Peter French <peterf@arnie.cfi.unsw.edu.au>
Subject: Re:

Harvey C, French PW (2000). Effects on protein kinase C and gene expression in a human mast cell line, HMC-1, following microwave exposure. Cell Biology International;23(11):739-48.

ABSTRACT

We used a resonant cavity which delivered a continuous wave exposure at 864.3 MHz at an average specific absorption rate (SAR) of 7W/kg  to determine non-thermal biological effects of microwave exposure. A human mast cell line, HMC-1, was used as the biological target. Cells were given three exposures each of 20 minutes duration daily for 7 days. The temperature of the cell culture medium during the exposure fell to 26.5oC.

Effects were seen on localisation of protein kinase C, and expression of three genes of 588 screened. The affected genes included the proto-oncogene c-kit, the transcription factor Nucleoside diphosphate kinase B and the apoptosis associated gene DAD-1. Stress response genes were variably upregulated. No significant effect on morphology or on F-actin distribution was detected.

We conclude that low power microwave exposure may act on HMC-1 cells by altering gene expression via a mechanism involving activation of protein kinase C, and at temperatures well below those known to induce a heat shock response.

EMRAA (Electromagnetic Radiation Alliance Australia)
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